Lehrstuhl für Zell- und Entwicklungsbiologie

RESEARCH TOPICS

Human trypanosomiasis and its animal form Nagana are a prime examples for the One Health concept

The exchange of surface coats is the phenotypic hallmark of antigenic variation. But in fact, this is just the tip of an iceberg

Trypanosomes enter the mammalian host with the bite of a hungry tsetse.

What do they do in the skin?

The trypanosome flagellum always beats. Motion is essential for immune escape, tsetse passage - and it is a very complex business

Trypanosomes limit the population size in the host by quorum sensing. What is the trigger?

Surface coat dynamics

The trypanosome VSG layer is a good model for fundamental studies on protein mobility.

Structure of the cell surface

The structure of the trypanosome surface coat is much more dynamic and flexible than generally assumed

Trafficking of GPI-proteins

Lipid-anchoring has implications on the sorting and trafficking of cell surface coat molecules

The tsetse fly provides a self-contained environment for adaptive morphogenesis of trypanosome microswimmers

The nuclear envelope provides the central platform for meiotic chromosome pairing and synapsis and is lynchpin for nuclear shaping during sperm formation.

Various aspects of mRNA metabolism in trypanosomes are related to the regulation of gene expression.

Trypanosomes have heavily invested in their microtubule-based cytoskeleton, but their actomyosin system is reduced.

Cell Adhesion is more than a handshake between binders. What role does physics play?

 

We employ cell models and model cells to shed light on membranes as multitasking organelles at the cellular interface with the outside.

“The most beautiful things in the world cannot be seen…” (Saint-Exupery), but we try anyways.

Telomer structure & function

We want to know how telomere-binding complexes influence anti-genic variation, chromosome integrity and recombination events

Chromatin & Differentiation

We want to learn why changes in chromatin structure and nuclear architecture is important for developmental differentiation in trypanosomes.

Regulation of replication

We want to investigate how the histone methyltransferase DOT1A regulates replication initiation in African trypanosomes

Kontakt

Lehrstuhl für Zoologie I - Zell- und Entwicklungsbiologie
Am Hubland
97074 Würzburg

Tel.: +49 931 31-84250
Fax: +49 931 31-84252
E-Mail

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Hubland Süd, Geb. B1 Hubland Nord, Geb. 32 Julius-von-Sachs-Platz 2 Fabrikschleichach Hubland Süd, Geb. B2 Campus Medizin