We study the adaptive and dynamic pleomorphism of parasites on the molecular, cellular and organismal level
Human trypanosomiasis and its animal form Nagana are a prime examples for the One Health concept
The exchange of surface coats is the phenotypic hallmark of antigenic variation. But in fact, this is just the tip of an iceberg
Trypanosomes enter the mammalian host with the bite of a hungry tsetse.
What do they do in the skin?
The trypanosome flagellum always beats. Motion is essential for immune escape and tsetse passage - and it is a very complex business
Trypanosomes limit the population size in the host by quorum sensing. What is the trigger?
Surface Coat Dynamics
The trypanosome VSG layer is a good model for fundamental studies on protein mobility.
Structure of the cell surface
The structure of the trypanosome surface coat is much more dynamic and flexible than generally assumed
Trafficking of GPI-proteins
Lipid-anchoring has implications on the sorting and trafficking of cell surface coat molecules
The tsetse fly provides a self-contained environment for adaptive morphogenesis of trypanosome microswimmers