Our current research is mainly focused on the function of nucleocytoplasmic network systems in nuclear shaping and meiotic chromosome dynamics. We are also interested in general regulation of chromosome synapsis and in evolutionary aspects of meiosis
LINC Complexes in Nuclear Shaping
A hallmark of sperm formation is the highly regulated species-specific shaping of the cell nucleus. We try to understand how germ cell nuclei actually change their specific shape from round to elongate.
The nuclear envelope in meiotic chromosome dynamics
Meiosis essentially requires an unambiguous assignment of the homologous chromosomes to ensure their proper segregation. We try to understand the specific function of the nuclear envelope during this core process of meiosis.
Evolution of the synaptonemal complex (SC)
Meiosis is highly conserved in eukaryotic evolution. But whether this is also true for the synaptonemal complex, a unique and vitally important supporting structure, was in dispute. In the past years we could provide evidence that at least in metazoans the SC has an common origin.