Epigenetics and Development
Trypanosomes developed a complicated life cycle in order to shuttle between a vertebrate host and an insect vector needed for transmission. They have to change their morphology, metabolism and energy sources to adapt to different hosts and changes in chromatin structure and nuclear architecture have been observed during this process. We use this parasite as a model organism to unravel the mechanisms that allow trypanosomes to adapt to extremely different environments in different host organisms.
In another project, we want to understand how post-translational histone modifications (PTMs) regulate cell cycle progression in Trypanosoma brucei. Individual projects are described below.