Welcome to Zoology I
For more than a century Cell and Developmental Biology has been one major research focus at the Zoological Institute of the Julius-Maximilians-University in Würzburg. Here, Theodor Boveri founded the chromosome theory of inheritance and Hans Spemann did his habilitation.
Today, our recently refurbished department continues to provide an inspiring scientific environment for several committed research groups. We work on basic aspects of membrane biology as well as on cell motility, meiosis, epigenetics or control of gene expression.
Our approach is always quantitative and interdisciplinary using state-of-the art technology. We promote the deadly African trypanosomes as powerful cell biological model system, but also work with mammalian and yeast cells, C. elegans, the claw frog Xenopus and the enigmatic hydra.
Besides our passion for science we are dedicated teachers. Each year hundreds of students attend our newly designed practical courses, seminars and lectures.
Marius Glogger, Ines Subota, Anna Pezzarossa, Anna-Lena Denecke, Mark Carrington, Susanne F. Fenz , Markus Engstler
Research on trypanosomes as a model organism has provided a substantial contribution to a detailed understanding of basic cellular processes within the last few years. At the same time, major advances in super-resolution microscopy have been achieved, facilitating the resolution of biological structures in living cells at a scale of a few nm. However, the motility of trypanosomes has prevented access to high resolution microscopy of live cells. Here, we present a hydrogel based on poly(ethylene glycol) functionalized with either norbornene or thiol moieties for UV induced thiol-ene crosslinking for the embedding and imaging of live trypanosomes. The resulting gel exhibits low autofluorescence properties, immobilizes the cells efficiently on the nanometer scale and is compatible with cell viability for up to one hour at 24 °C. We applied super-resolution imaging to the inner plasma membrane leaflet using lipid-anchored eYFP as a probe. We find specific domains within the membrane where the fluorescence either accumulates or appears diluted rather than being homogenously distributed. Based on a Ripley's analysis, the size of the domains was determined to be raccumulated = (170 ± 5) nm and rdilute> (115 ± 15) nm. We hypothesize that this structuring of the membrane is associated with the underlying cytoskeleton.
From 19. - 24. of March the DPG spring meeting of the Condensed Matter Section took place in Dresden. The program in the Biological Physics division ranged from Single-Molecule Biophysics to Physics of Parasites. 20 invited and 170 contributing speakers reported on the latest developments in biophysics research. Two lively poster sessions provided the perfect opportunity to discuss in a relaxed atmosphere with beer&bretzels. Laurens W. Molenkamp (Experimental Physics, University of WÃ¼rzburg) the Laureate of the Stern-Gerlach-Medaille 2017 spoke about Topological Insulators: a New State of Matter. Work of the Department of Cell-and Developmental Biology was presented in two talks by Markus Engstler 'Deadly microswimmers - how trypanosomes move in blood and navigate in the tsetse fly' and Susanne Fenz 'Live-cell super-resolution imaging of intrinsically fast moving flagellates'. … MORE