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For more than a century Cell and Developmental Biology has been one major research focus at the Zoological Institute of the Julius-Maximilians-University in Würzburg. Here, Theodor Boveri founded the chromosome theory of inheritance and Hans Spemann did his habilitation. Today, our recently refurbished department continues to provide an inspiring scientific environment for several committed research groups. We work on basic aspects of membrane biology as well as on cell motility, meiosis, epigenetics or control of gene expression. Our approach is always quantitative and interdisciplinary using state-of-the art technology. We promote the deadly African trypanosomes as powerful cell biological model system, but also work with mammalian and yeast cells, C. elegans, the claw frog Xenopus and the enigmatic hydra. Besides our passion for science we are dedicated teachers. Each year hundreds of students attend our newly designed practical courses, seminars and lectures.


January 13,

ZEB Seminar

PD Dr. Thomas Müller-Reichert
Medical Theoretical Center (MTZ), TU Dresden
"In and out of mitosis - Correlative light and electron microscopy for structural cell biology"
29.01.2015, 9.15 Uhr, Biozentrum, Hörsaal A103

January 13,

ZEB Seminar

Prof. Dr. Albrecht Müller
Molekulare Strahlenbiologie / Medizinische Strahlenkunde am Lehrstuhl für Medizinische Strahlenkunde und Zellforschung
"Getting to the root of Polycomb function in ESCs and HSCs"
15.01.2015, 9.15 Uhr, Biozentrum, Hörsaal A103

January 09,

Simulating the Complex Cell Design of Trypanosoma brucei and its Motility

Typanosoma brucei is a uni-cellular parasite that causes sleeping sickness, a deadly disease for humans that also occurs in livestock. Alizadehrad et al. have developed an accurate, in silico model trypanosome using information from live cell analyses. … MORE

December 15,

Center for Computational and Theoretical Biology

18.12.2014 Inaugural Lecture Series One … MORE

19.12.2014 Inaugural Lecture Series Two … MORE

09.01.2015 Inaugural Lecture Series Three … MORE

13.01.2015 Inaugural Lecture Series Four … MORE

December 11,

Association Rates of Membrane-Coupled Cell Adhesion Molecules

Timo Bihr, Susanne Fenz, Erich Sackmann, Rudolf Merkel, Udo Seifert, Kheya Sengupta, Ana-Sunčana Smith
ABSTRACT Thus far, understanding how the confined cellular environment affects the lifetime of bonds, as well as the extraction of complexation rates, has been a major challenge in studies of cell adhesion. Based on a theoretical description of the growth curves of adhesion domains, we present a new (to our knowledge) method to measure the association rate kon of ligand-receptor pairs incorporated into lipid membranes. As a proof of principle, we apply this method to several systems. We find that the kon for the interaction of biotin with neutravidin is larger than that for integrin binding to RGD or sialyl Lewisx to E-selectin. Furthermore, we find kon to be enhanced by membrane fluctuations that increase the probability for encounters between the binders. The opposite effect on kon could be attributed to the presence of repulsive polymers that mimic the glycocalyx, which points to two potential mechanisms for controlling the speed of protein complexation during the cell recognition process. … MORE

December 01,

ZEB Seminar

Katrin Heinze
Virchow Zentrum Würzburg
"Challenges and solutions in today's biomedical fluorescence imaging"
04.12.2014, 9.15 Uhr, Biozentrum, Hörsaal A103

November 17,

ZEB Seminar

Prof. Dr. Doris Heinrich
Institute of Physics, Uni Leiden
"Cell dynamics- from intracellular transport to artificial tissue"
20.11.2014, 9.15 Uhr, Biozentrum, Hörsaal A103

November 17,

Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes.

Gülcin Dindar, Andreas M. Anger, Christine Mehlhorn, Sandra B. Hake & Christian J. Janzen
Nature communication 5, Article number: 5313 doi:10.1038/ncomms6313

DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone ​H3. Most eukaryotes contain one DOT1 enzyme, whereas African trypanosomes have two homologues, ​DOT1A and ​DOT1B, with different enzymatic activities. We employed a trypanosomal nucleosome reconstitution system and structure-guided homology modelling to identify critical residues within and outside the catalytic centre that modulate product specificity of these enzymes. … MORE

November 12,

Boveri’s microscopic slides back in Würzburg.

Famous cell biologist Joe Gall donates original slides to complete the unique selection of Boveri’s histological specimen in Würzburg. … MORE

November 11,

CDK2 and the dynamics of telomeres and nuclear envelope proteins in meiotic cells

Viera, A., M. Alsheimer, R. Gómez, I. Berenguer, S. Ortega, C.E. Saymonds, D. Santamaría, R. Benavente & J.A. Suja: CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J. Cell Sci. doi:10.1242/jcs.154922 … MORE

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