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Welcome



For more than a century Cell and Developmental Biology has been one major research focus at the Zoological Institute of the Julius-Maximilians-University in Würzburg. Here, Theodor Boveri founded the chromosome theory of inheritance and Hans Spemann did his habilitation. Today, our recently refurbished department continues to provide an inspiring scientific environment for several committed research groups. We work on basic aspects of membrane biology as well as on cell motility, meiosis, epigenetics or control of gene expression. Our approach is always quantitative and interdisciplinary using state-of-the art technology. We promote the deadly African trypanosomes as powerful cell biological model system, but also work with mammalian and yeast cells, C. elegans, the claw frog Xenopus and the enigmatic hydra. Besides our passion for science we are dedicated teachers. Each year hundreds of students attend our newly designed practical courses, seminars and lectures.

News


December 15,
2014

Center for Computational and Theoretical Biology


18.12.2014 Inaugural Lecture Series One … MORE

19.12.2014 Inaugural Lecture Series Two … MORE

09.01.2015 Inaugural Lecture Series Three … MORE

13.01.2015 Inaugural Lecture Series Four … MORE


December 11,
2014

Association Rates of Membrane-Coupled Cell Adhesion Molecules


Timo Bihr, Susanne Fenz, Erich Sackmann, Rudolf Merkel, Udo Seifert, Kheya Sengupta, Ana-Sunčana Smith
ABSTRACT Thus far, understanding how the confined cellular environment affects the lifetime of bonds, as well as the extraction of complexation rates, has been a major challenge in studies of cell adhesion. Based on a theoretical description of the growth curves of adhesion domains, we present a new (to our knowledge) method to measure the association rate kon of ligand-receptor pairs incorporated into lipid membranes. As a proof of principle, we apply this method to several systems. We find that the kon for the interaction of biotin with neutravidin is larger than that for integrin binding to RGD or sialyl Lewisx to E-selectin. Furthermore, we find kon to be enhanced by membrane fluctuations that increase the probability for encounters between the binders. The opposite effect on kon could be attributed to the presence of repulsive polymers that mimic the glycocalyx, which points to two potential mechanisms for controlling the speed of protein complexation during the cell recognition process. … MORE


December 01,
2014

ZEB Seminar


Katrin Heinze
Virchow Zentrum Würzburg
"Challenges and solutions in today's biomedical fluorescence imaging"
04.12.2014, 9.15 Uhr, Biozentrum, Hörsaal A103


November 17,
2014

ZEB Seminar


Prof. Dr. Doris Heinrich
Institute of Physics, Uni Leiden
"Cell dynamics- from intracellular transport to artificial tissue"
20.11.2014, 9.15 Uhr, Biozentrum, Hörsaal A103


November 17,
2014

Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes.


Gülcin Dindar, Andreas M. Anger, Christine Mehlhorn, Sandra B. Hake & Christian J. Janzen
Nature communication 5, Article number: 5313 doi:10.1038/ncomms6313

DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone ​H3. Most eukaryotes contain one DOT1 enzyme, whereas African trypanosomes have two homologues, ​DOT1A and ​DOT1B, with different enzymatic activities. We employed a trypanosomal nucleosome reconstitution system and structure-guided homology modelling to identify critical residues within and outside the catalytic centre that modulate product specificity of these enzymes. … MORE


November 12,
2014

Boveri’s microscopic slides back in Würzburg.


Famous cell biologist Joe Gall donates original slides to complete the unique selection of Boveri’s histological specimen in Würzburg. … MORE


November 11,
2014

CDK2 and the dynamics of telomeres and nuclear envelope proteins in meiotic cells


Viera, A., M. Alsheimer, R. Gómez, I. Berenguer, S. Ortega, C.E. Saymonds, D. Santamaría, R. Benavente & J.A. Suja: CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J. Cell Sci. doi:10.1242/jcs.154922 … MORE


November 06,
2014

ZEB-Seminar


Dr. Falk Butter, Institute of Molecular Biology, Mainz:
‘Quantitative Proteomics for Biology'
09:15 A102


October 14,
2014

Vortrag vor 500 Schülern:


Ebola & Co.: Wenn vernachlässigte Tropenkrankheiten Schlagzeilen machen.

… MORE


October 06,
2014

The Faculty of Biology announces the ‘Center for Computational and Theoretical Biology’.


The CCTB is an independent scientific unit that will be located in newly renovated rooms at the Würzburg Campus Hubland Nord. Four junior professors covering very different aspects of computational biology will form the core of the CCTB.
… MORE


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