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For more than a century Cell and Developmental Biology has been one major research focus at the Zoological Institute of the Julius-Maximilians-University in Würzburg. Here, Theodor Boveri founded the chromosome theory of inheritance and Hans Spemann did his habilitation. Today, our recently refurbished department continues to provide an inspiring scientific environment for several committed research groups. We work on basic aspects of membrane biology as well as on cell motility, meiosis, epigenetics or control of gene expression. Our approach is always quantitative and interdisciplinary using state-of-the art technology. We promote the deadly African trypanosomes as powerful cell biological model system, but also work with mammalian and yeast cells, C. elegans, the claw frog Xenopus and the enigmatic hydra. Besides our passion for science we are dedicated teachers. Each year hundreds of students attend our newly designed practical courses, seminars and lectures.


March 02,

ZEB Seminar

Prof. Dr. Ada Olins and Prof. Dr. Don Olins
College of Pharmacy, University of New England, Portland, Maine, USA
"Nuclear Architecture in a Myeloid Leukemic Cell"
05.03.2015, 9.15 Uhr, Biozentrum, Hörsaal A103

February 24,

Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements

Link, J., Jahn, D. and Alsheimer, M. (2015). Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements. Nucleus, doi: 10.1080/19491034.2015.1004941 … MORE

February 03,

Super-resolution imaging of the synaptonemal complex

Schücker, K., T. Holm, C. Franke, M. Sauer & R. Benavente: Elucidation of synaptonemal complex structure by super-resolution imaging with isotropic resolution. Proc. Natl. Acad. Sci. USA 112: doi:10.1073/pnas.1414814112 … MORE

February 02,

BioSciences Würzburg

The interdisciplinary Department for Cell and Developmental Biology introduced to 2nd and 3rd years students … MORE

January 13,

ZEB Seminar

PD Dr. Thomas Müller-Reichert
Medical Theoretical Center (MTZ), TU Dresden
"In and out of mitosis - Correlative light and electron microscopy for structural cell biology"
29.01.2015, 9.15 Uhr, Biozentrum, Hörsaal A103

January 13,

ZEB Seminar

Prof. Dr. Albrecht Müller
Molekulare Strahlenbiologie / Medizinische Strahlenkunde am Lehrstuhl für Medizinische Strahlenkunde und Zellforschung
"Getting to the root of Polycomb function in ESCs and HSCs"
15.01.2015, 9.15 Uhr, Biozentrum, Hörsaal A103

January 09,

Simulating the Complex Cell Design of Trypanosoma brucei and its Motility

Typanosoma brucei is a uni-cellular parasite that causes sleeping sickness, a deadly disease for humans that also occurs in livestock. Alizadehrad et al. have developed an accurate, in silico model trypanosome using information from live cell analyses. … MORE

December 15,

Center for Computational and Theoretical Biology

18.12.2014 Inaugural Lecture Series One … MORE

19.12.2014 Inaugural Lecture Series Two … MORE

09.01.2015 Inaugural Lecture Series Three … MORE

13.01.2015 Inaugural Lecture Series Four … MORE

December 11,

Association Rates of Membrane-Coupled Cell Adhesion Molecules

Timo Bihr, Susanne Fenz, Erich Sackmann, Rudolf Merkel, Udo Seifert, Kheya Sengupta, Ana-Sunčana Smith
ABSTRACT Thus far, understanding how the confined cellular environment affects the lifetime of bonds, as well as the extraction of complexation rates, has been a major challenge in studies of cell adhesion. Based on a theoretical description of the growth curves of adhesion domains, we present a new (to our knowledge) method to measure the association rate kon of ligand-receptor pairs incorporated into lipid membranes. As a proof of principle, we apply this method to several systems. We find that the kon for the interaction of biotin with neutravidin is larger than that for integrin binding to RGD or sialyl Lewisx to E-selectin. Furthermore, we find kon to be enhanced by membrane fluctuations that increase the probability for encounters between the binders. The opposite effect on kon could be attributed to the presence of repulsive polymers that mimic the glycocalyx, which points to two potential mechanisms for controlling the speed of protein complexation during the cell recognition process. … MORE

December 01,

ZEB Seminar

Katrin Heinze
Virchow Zentrum Würzburg
"Challenges and solutions in today's biomedical fluorescence imaging"
04.12.2014, 9.15 Uhr, Biozentrum, Hörsaal A103

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